The main aim of EDEC group is to improve environmental risk assessment of endocrine disrupting chemicals (EDCs) and emerging pollutants (EPs) in aquatic ecosystems, developing new methodologies to assess their effects. Addressing the impact of deep-sea mining and accidental marine spills are also current research aims. The group uses a multi-parametric approach that combines molecular biology, modeling and bioinformatics, ecological modeling, biochemical tools, and population relevant endpoints such as embryonic development bioassays, full life-cycle and multi and transgenerational assays. We aim to understand the mechanisms of toxicity of EDCs and EPs, single and in mixtures, and their impact in the aquatic ecosystems. We are particularly interested in understanding the transgenerational effects of EDECs and EPs and the underlying MOA. We use ecological modeling to project the ecological costs associated with chemical exposure. Linking adverse-effects endpoints of EDCs and EPs with the chemical’s mode of action (MOA) is transversal to all themes of the EDEC group. Our approach takes into consideration an evolutionary perspective thus focusing on the impact of EDCs and EPs across different phyla. Since the endocrinology and the genomic constitution of most invertebrates are poorly characterized, a parallel aim is to improve the understanding of invertebrate’s endocrinology and signaling pathways and link it with the impact of EDCs in key biological process. The group combines both field and laboratory studies
ENDOCRINE DISRUPTORS AND EMERGENT CONTAMINANTS
Ruivo R., Bellenchi G.C., Chen X., Zifarelli G., Sagné C., Debacker C., Pusch M., Supplisson S., Gasnier B. (2012). Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin. Proc Natl Acad Sci U S A, 109(5): E210-217.
Castro L.F., Santos M.M. (2014). To bind or not to bind: the taxonomic scope of nuclear receptor mediated endocrine disruption in invertebrate phyla. Environmental Science and Technology, 48(10): 5361-5363.
Neuparth T., Martins C., de los Santos C.B., Costa M.H., Martins I., Costa P.M., Santos M.M. (2014). Hypocholesterolaemic pharmaceutical simvastatin disrupts reproduction and population growth of the amphipod Gammarus locusta at the ng/L range. Aquatic Toxicology, 155: 337-347.
Cardoso PG, Rodrigues D, Madureira TV, Oliveira N, Rocha MJ, Rocha E (2017). Warming modulates the effects of the endocrine disruptor progestin levonorgestrel on the zebrafish fitness, ovary maturation kinetics and reproduction success. Environmental Pollution. 229: 300-311.
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- CORAL: Sustainable Ocean Exploitation: Tools and Sensors
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- ValorMar: Integral valuation of marine resources: potential, technological innovation and new applications
- GLOBALED: Impacts of global change on environmentally realistic mixtures of endocrine disruptor compounds on the structure and functioning of coastal ecosystems. Implications for a sustainable environment
- NanoLegaTox: When old meets new: A novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures
- NOR-WATER: Pollutants of emerging concern in watersheds from Galicia-Northern Portugal: new tools to risk management
- TRANSobesogen: Trans-phyletic obesogenic responses: from epigenetic modules to transgenerational environmental impacts
- ATLANTIDA: Platform for the monitoring of the North Atlantic ocean and tools for the sustainable exploitation of the marine resources