Invited Talk | Amaranta Kahn | 10 Jan


Title: Engineering of hyperthermophilic designer cellulosomes.


Name: Amaranta Kahn


Affiliation: Weizmann Institute of Science


Enzymatic breakdown of cellulose is the major challenge in the conversion of cellulose to biofuel. In that context, the use of hyper-thermostable enzymes (highly suited for processing conditions) from Caldicellulosiruptor bescii, a very efficient cellulolytic bacterium, could be assembled into “cellulosome” complexes, which are proven to be highly effective in cellulose deconstruction.  We therefore fabricated enzymatic complexes: designer cellulolosomes composed of a thermophilic scaffoldin and chimaeric cellulosomal C. bescii enzymes. The results of this study demonstrated that these complexes were highly thermostable, and that synergy could be reached having some of the compounds glycosylated.


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