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Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents

The need for a continued search for new anti-infective and anticancer drugs is universally considered of great importance since many of the current drugs are insufficiently effective, highly toxic, and resistances may be developed. Two alkaloids, being eurochevalierine a potent inhibitor of the growth of human tumor cell lines, were isolated from the soil fungus Neosartorya pseudofischeri, and neofiscalin A from the soil and marine fungus N. siamensis with potent antibacterial activity. Neofiscalin A exhibited also antibiofilm activity in both reference and multidrug-resistant isolates, and is currently in the patent filing process. These compounds and their derivatives are under study in order to obtain quantities as well as for more biological assays. On the other hand, marine fungi derived xanthones, particularly yicathins and isomers were considered promising as chemotherapic agents. So, eurochevalierine, neofiscalin A and yicathins can be considered very interesting models to discover new anti-infective and anticancer drugs to overcome drug-resistance that could represent innovative drug candidates. However, their availability to proceed to further investigations and their complex structures could limit their future as drug candidates. Our goal is not only to continue the search for innovative marine-derived compounds but also to obtain derivatives/formulations of the most promising compounds to obtain more efficient analogues and more effective delivery systems.

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