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EVOLUTIONARY GENOMICS AND BIOINFORMATICS

Principal Investigator:
Agostinho Antunes

The research developed comprehends several distinct areas within the field of genetics, such as comparative genomics, molecular evolution and natural selection studies, toxicogenomics , microbial genomics, software development and bioinformatics, modeling of interactions protein/toxin, genetic diversity of toxic invasive species, conservation genetics and ecological studies in endemics or endangered species and wildlife trade and bushmeat genetics.

TEAM

Publications Highlights

Zhang G., Antunes A., et al. 2014. Comparative Genomics Reveals Insights into Avian Genome Evolution and Adaptation. Science, 346(6215): 1311-1320.

Dutertre S., Jin A., Vetter I., Hamilton B., Sunagar K., Lavergne V., Dutertre V., Fry B.G., Antunes A., Venter D., Alewood P., Lewis R. 2014. Evolution of separate predation- and defence-evoked venoms in carnivorous snails. Nature communications, 5: 3521.

Choo SW, Antunes A, et al. 2016. Pangolin genomes and the evolution of mammalian scales and immunity. Genome Research, 26(10): 1312-1322.

Escalona T., Weadick C.J., Antunes A. 2017. Adaptive patterns of mitogenome evolution are associated with the loss of shell scutes in turtles. Molecular Biology and Evolution, 34(10): 2522-2536.

Khan I., Yang Z., Maldonado E., Li C., Zhang G., Gilbert M.T.P., Jarvis E.D., O’Brien S.J., Johnson W.E., Antunes A. 2015. Olfactory receptor subgenomes linked with broad ecological adaptations in Sauropsida. Molecular Biology and Evolution, 32(11): 2832-2843.

Dobrynin P, Antunes A, et al. 2015. Genomic Legacy of the African Cheetah, Acinonyx jubatus. Genome Biology, 16(1): 277.

Sunagar K., Johnson W.E., O’Brien S.J., Vasconcelos V., Antunes A. 2012. Evolution of CRISPs associated with toxicoferan-reptilian venom and mammalian reproduction. Molecular Biology and Evolution, 29(7): 1807-1822.

Philip S., Machado J.P., Maldonado E., Vasconcelos V., O'Brien S.J., Johnson W.E., Antunes A. 2012. Fish lateral line innovation: insights into the evolutionary genomic dynamics of a unique mechanosensory organ. Molecular Biology and Evolution, 29(12): 3887-3898.

Antunes A., Troyer J.L., et al. 2008. The evolutionary dynamics of Lion Panthera leo revealed by host and viral population genomics. PLoS Genetics, 4(11): e1000251.

Johnson W.E., Eizirk E., Murphy W.J., Pecon-Slaterry J., Antunes A., Teeling E., O’Brien S.J. 2006. The late Miocene radiation of the Felidae: a genetic assessment. Science, 311:73-77.

Projects