Due to the physical and chemical conditions, the marine environment is an exceptional reservoir of bioactive natural products, many of which exhibit unique structural features not found in terrestrial counterparts. In the past years, there has been an increasing interest on marine-derived fungi as a target source of bioactive marine natural products because many consider them among the world’s greatest untapped resources for new biodiversity as well as chemodiversity. Additionally, through established culture methods, they can produce quantity of compounds needed for medicinal chemistry development, clinical trials and even marketing. Therefore, the objective of our research team is to search for secondary metabolites, especially with unique structural feature, produced by the cultures of the fungi associated with different types of marine macro-organisms from different habitats. Different chromatographic techniques are used to isolate and purify the metabolites from the extract. The structures of the compounds are established by extensive analysis of spectroscopic data such as 1D and 2D NMR and HRMS. X-ray analysis, comparison of calculated and experimental ECD spectra and chiral chromatographic analysis are used to establish the absolute stereochemistry of the compounds. The isolated compounds will be further evaluated for their biological activities by the bioassay platform.
CHEMISTRY AND BIOLOGICAL ACTIVITY OF MARINE NATURAL PRODUCTS
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