Principal Investigator:
Madalena Pinto

The main interest is the searching for new pharmacologically active compounds from natural or synthetic origin, through competencies in the rational design, synthesis, structure elucidation, determination of biophysicochemical parameters of bioactive compounds, their biological activities investigation as well as the development of safer environmental products. The long term objective is to obtain novel compounds based on innovative marine bioproducts which can be used as new chemical entities and potential biomedicines and their economic valorization by patent protection.

Publications Highlights

Long, S.; Resende, D.; Kijjoa, A.; Silva, A.; Tiritan, M.E.; Pereira-Terra, P.; Freitas Silva, J.; Barreiro, S.; Silva, R.; Remião, F.; Pinto, E.; Costa, P.; Sousa, M.E.; Pinto, M. (2020). New Marine-Derived Indolymethyl Pyrazinoquinazoline Alkaloids with Promising Antimicrobial Profiles. RCSAdvances,10(52):31187-31204. 

Almeida, J.R., Palmeira, A., Campos, A., Cunha, I., Freitas, M., Felpeto, A.B., Turkina, M.V., Vasconcelos, V., Pinto. M., Correia-da-Silva, M. and Sousa, E. (2020).  Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones, Biomolecules

Loureiro, D.R.P., Magalhães, A.F., Soares, J.X., Pinto, J., Azevedo, C.M.G., Vieira, S., Henriques, A., Ferreira, H., Neves, N., Bousbaa, H., Reis, S., Afonso, C.M.M., and Pinto, M.M.M. (2020). Yicathins B and C and Analogues: Total Synthesis, Lipophilicity and Biological Activities, ChemMedChem, 15, 1-8.

Pinto, P., Machado, C.M., Moreira, J., Almeida, J. D.P., Silva, P.M.A., Henriques, A.C., Soares, J.X., Salvador, J.A.R., Afonso, C., Pinto; M., Bousbaa, H., Cidade. H. (2019). Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity, European Journal of Medicinal Chemistry 184, 111752, 1-14. 

Araújo, J., Fernandes, C., Pinto, M. and Tiritan, M.E. (2019). Chiral Derivatives of Xanthones with Antimicrobial Activity. Molecules, 24, 314.