Principal Investigator:
Madalena Pinto

The main interest is the searching for new pharmacologically active compounds from natural or synthetic origin, through competencies in the rational design, synthesis, structure elucidation, determination of biophysicochemical parameters of bioactive compounds, their biological activities investigation as well as the development of safer environmental products. The long term objective is to obtain novel compounds based on innovative marine bioproducts which can be used as new chemical entities and potential biomedicines and their economic valorization by patent protection.

Publications Highlights

Almeida J.R., Correia-da-Silva M., Sousa E., Antunes J., Pinto M., Vasconcelos V., Cunha I. (2017). Antifouling potential of Nature-inspired sulfated compounds. Scientific Reports, 7: 42424.

Cidade H., Rocha V., Palmeira A., Marques C., Tiritan M.E., Ferreira H., Lobo J.S., Almeida I.F., Sousa M.E., Pinto M. (2017). In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives. Arabian Journal of Chemistry.

Fernandes C., Tiritan M.E., Cravo S., Phyo Y., Kijjoa A., Silva A.M.S., Cass Q.B., Pinto M.M.M. (2017). New chiral stationary phases based on xanthone derivatives for liquid chromatography, Chirality.

Long S., Sousa E., Kijjoa A., Pinto M. (2016). Marine natural products as models to circumvent multidrug resistance. Molecules, 21: 892.

Pereira D., Lima R.T., Palmeira A., Seca H., Soares J., Gomes S., Raimundo L., Maciel C., Pinto M., Sousa E., Vasconcelos M.H., Saraiva L., Cidade H. (2016). Design and synthesis of new inhibitors of p53-MDM2 interaction with a chalcone scaffold, Arabian Journal of Chemistry.